Semi Solids in Ndds

INTRODUCTION:  Novel semisolids are non greasy since they are made up of water washable bases. Hence they cause less irritation to skin and are superior to conventional semisolid dosage form.  Novel creams now a days are provided with nanoparticles and microspheres, which has an excellent emollient effect, with better spreadability, and less staining than oleaginous ointments. However both medicated and non-medicated creams provide very good emollient effects, oleaginous ointments are preferred for dry, chapped skin in an environment of low humidity because of its occlusive properties.  Number of innovation has been taken place in gels in term of modification of release pattern and also some thermoreversible gels are also introduced. Complex gels for Ora / Insulin delivery, chitosan based bioadhesive gels and TIMERx technology for controlled release, amphiphilic and non-aqueous gels are also the latest innovations in gel formulations.  Number of new bases for Gels, Ointment and Creams are developed which facilitates the delivery of above novel semisolids by various route like Nasal, Parentral or Ophthalmic route.  Care should also be used in applying any drug to inflamed skin. The integrity of inflamed skin is generally compromised, resulting in increased percutaneous migration and systemic absorption of most drugs.